Natural Origin PureKIC® (Alpha-Ketoisocaproate Calcium) provides high purity of KIC, free from the foul odour.

Alpha-ketoisocaproate (KIC) is a keto acid of the amino acid leucine. Branched-chain keto acids are very similar to branched-chain amino acids, the only difference being the presence of a keto group instead of an amino group. KIC is anticatabolic, which means it contributes to muscle growth by helping to move the body from a catabolic (muscle wasting) to anabolic (muscle building) state.

ARG-KIC(L-Arginine KIC Combo) is available at the same time.

According to an NCBI study, More than 70% of athletes report using nutritional supplements to improve health and sports performance []; however, few supplements have shown ergogenic potential under controlled experimental conditions []. Alpha-ketoisocaproic acid (KIC), the ketoacid of leucine, has been shown to enhance high-intensity exercise performance when consumed in combination with glycine and L-arginine (GAKIC) [,], reduce exercise-induced muscle damage and preserve skeletal muscle force production when ingested with β-hydroxy-β-methyl butyrate (HMB).

With moderate- and high-intensity exercise, factors such as total energy supply or local muscle fatigue may limit maximal anaerobic power [] through reduced force output in skeletal muscle []. Theoretically, supplemental KIC may enhance exercise performance by 1) promoting total muscle energy supply, [,,] 2) attenuating NHaccumulation, [,] 3) and reducing exercise-induced muscle damage []. For example, PureKIC® (Alpha-Ketoisocaproate Calcium) administration is purported to spare glucose utilization by skeletal muscle, possibly by inhibiting glycogen deposition and/or the pyruvate dehydrogenase enzyme complex in skeletal muscle [,].

Further, the liver can convert KIC to ketone bodies [,], thus increasing the potential energy supply during exercise []. Additionally, PureKIC® (Alpha-Ketoisocaproate Calcium) is readily dehydrogenase to leucine, via leucine dehydrogenase and branched-chain amino acid transferase at the expense of NH3, in a variety of tissues, including skeletal muscle, [,,] which may ultimately decrease fatigue and preserve lean muscle force production during intense exercise [].